I've used pretty much all the more powerful, flatter-shooting rounds available, over the last 50 or so years - but for the last 10 or so, I've found I can do without the attendant muzzle blast & recoil, and have reverted to the .30-30 & .300 Savage for all my shooting on game larger than small game/varmints.

FWIW, the .30-30's cheaper to feed, too.

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It ain't no fun, when the rabbit's got the gun