I've shot a bull and a cow with handloaded 140gr. Nosler Partitions. 5x5 bull was a head shot at 80 yds. DRT! The cow was a angling front shoulder shot at a measure 426 yds. Bullet hit front shoulder and exited on the otherside near the hind quarter!!! Both shots fired from an 18" barreled Model 7. Shot several deer also with this load and I have never needed more than one shot so far. Hate to mess with something proven but will try some TSX soo.I haven't tried the Barnes bullets yet but am hoping for good results. I got a couple boxes to load but haven't gotten around to it yet.
Good Luck,
WW