A question for those with experience, the more the better.
Concerning a rifle for use in case of escaped big cats at expected ranges of 100 yards and less, in the U.S.
By an experienced shooter/hunter/handloader.

Any caliber preference between .375 H&H (or Ruger) and .458WM?

Based on my research (to date) I'm leaning pretty heavily right now toward .375 Ruger, 260 gr. Nosler Partition.
In a relatively short barrel rifle such as the Ruger Guide Gun but I'm watching the used market for .375 H&H, .416 and .458WM.
Weight is no concern to me but short/handy is.

The rifle will see quite a bit of practice and range time.

Basically I'm adding a rifle, in a caliber I don't have and want it to be close to ideal for main purpose mentioned, all else would be of secondary importance.

John