Full disclosure, I have never taken a big cat but plenty of my friends have and I have spoken with and read accounts of numerous Professional Hunters. The conventional wisdom is cats are very sensitive to high velocity calibers (and properly constructed bullets to match). There is also a big difference between a leopard and a lion. For me, speed kills baby so a 300 for leopard and a 375 for lion as fast as I can push them would be my recommendation.

A good principle to guide me through life: “This is all I have come to expect, standard lackluster performance. Trust nothing, believe no one and realize it will only get worse…”