I guess I'm one of the few going a little the other way. Started hunting with a 30-06 almost 25 years ago, gone through middling cartridges like the 6.5x55 Swede and 8x57 Mauser as well as 7-08 and 308, not to mention lever gun cartridges like 32-40 38-55 too but they are all gone now and truth be told, not at all missed. Alongside my faithful Tikka 30-06 my 243 and my 30-30 remain but I think I am ready to now want to try a magnum cartridge. I've settled on Remington's classic, the Magnificent Seven. I figure if I want 7-08 /7mm Mauser power, I can easily dial the Magnum down a bit but it's nice to have an extra gear or two available when i want it. I mean all you really need to go get your groceries is a 1985 Toyota Tercel but it is more enjoyable to take the Mustang out for a ride even if it burns a little more gas.
