.22 Long rifle on deer, .220 Swift on coyotes/mule deer/Black Buck antelope, Axis deer. .224 TTH on a huge hog, .221 fireball on a 70# hog, .22 Long rifle and .22 Magnum on hogs. My FIL "lost" a nice buck ( Tx) using a 55gr fmj .223. My BIL used a .22 Magnum on deer a lot. I myself lost a big hog by trying to shoot him between the eyes at 60yds off with a 22-250AI and a 55gr TB, I should have know better, it just skidded off that sloping forehead. I was on the ground, if I had been higher, up in a tower or tree I'd have had him. Oh well. Bullets and angles and distance are the key, and I could do 75% of what I did with the Swift with a .223. Most folks don't realize how small deer are in South and how close you can be to them. shooting them with a bigger centerfire is "almost" an embarrassment of riches, ha. I've used 300 mags on them, but the sierra 150 Pro Hunter acted like Partitions, which surprised me. I wanted a bomb that would "puff them up" like my 22-250 did coyotes, ha.