I’ve only used it on one white tail myself, but my buddies kids have used my cz 527 in 221 fireball for the last 3 years, killing 4 deer between them. They’ve all been shot with my handloads using 45gr tsx. All shot in the lungs, and 3 of the 5 dropped on the spot. The other two ran about 30 yards. Recovered 1 bullet, and the other 4 passed through. All shots were under 100yds. It’s amazing how much damage that little bullet can do.
Seriously... I may have to get a hornet load worked up and restrict it to bow ranges and see how it goes
