I like threads like this that show that big game was killed clean with.22's before fast twist and high BC bullets.
I have done it for years, although I still think there are better cartridges for deer. My wife with a 22-250, my daughter with a 223 and a couple more antelope with the 22-250. The nice thing about a great varmint cartridge is you can shoot them in the head, even at extended ranges...