I’ve killed a couple does with a 22-250 shooting 55 grain varmint bullets but both were head shots. I hunted a ranch in Texas that an old man owned and he swore by the 22-250 for deer but I swear that old man lost more deer that he shot than I can count. I couldn’t begin to testify to shot placement, I just know I spent a lot of nights with a flashlight looking for deer “he hit good”. I think these heavier bullets now available with fast twist barrels definitely adds an advantage to the 22 cal capability on deer/antelope sized game especially since accuracy can be so good, recoil non-existent and being able to watch the shot all the way through.
