I did the 300 to 375 choice but many very experienced hunters are fans of the 33's as their main rifle. Others say not enough difference to tell between a 300 and 33, I do think there is a difference between a 30 and 375 at least in reaction to the shot. The larger calibers are usually more reliable in producing a blood trail if one is needed. But this depends largely on shot placement and bullet performance.
A 300 I can go for about a box of shells the 338 less but the 375 may be even more tolerable than the 300s. The 340 Weatherby is over my recoil tolerance level for any sustained shooting. Varies with stock fit and weight so this is just a general observation for my tolerances.
"When you disarm the people, you commence to offend them and show that you distrust them either through cowardice or lack of confidence, and both of these opinions generate hatred." Niccolo Machiavelli
