I use a 243 quite a bit, and use the 100 grain Sierra Pro Hunter or GameKings. I've been fiddling with 100 grain Nosler Partitions, but so far no luck in my rifle with H 4350.
Most of my shots are in woods, with some open hayfields/pastures thrown in, anywhere from eyeball range to 200-250 yards.
I've not been disappointed in the Sierras, but like the idea of a better guarantee of an exit.