I knew a guy who shot a charging grizzly in the center of the chest with a 130 Speer out of a 270. Folded him up like a lawn chair.
I also know a couple guys who have killed about 30 elk with their 270s.

I’ve killed or seen them killed with bullets from .224 on up to .323s both standard and magnum cartridges. The one thing in common is with good placement they die quick and easy. Shoot a leg off and it gets ugly.