I really like a 30/06 but have killed more animals with my 338 than any other caliber, followed by my 30/06. I have 270’s, 7mags, 300win and 300wby magnums plus a bunch of calibers below and above. My choice would depend on where I hunt or plan to hunt. Its still a hard choice for me so I have multiple choices, limited to one, 30/06!