I believe the point some are trying to make here is that there is no bullet you can put into a small bore that will make it the equal of a big bore. How many would like to face an angry brown bear with a .270 Winchester loaded with Nosler Partitions?
Smokeless powder technology may have killed off most of the old blackpowder loads. But cartridges such as the .270 and 30/06 do not kill better, or perhaps even as well, as the old blackpowder big bores. They just allow you to hit more easily at longer range while still providing respectable killing power. That is why such loads as the .45 Colt and 45/70 are still with us. They work very dependably without reliance on modern bullets.