mathman,
I reloaded some of the brass 3 times with no problems so far. Not even a thought it was getting softer or loose pockets.
I use new brass for hunting, but use all my once, twice, etc. brass for sighting in. And out of my first batch of brass, it's holding up well so far.
I read somewhere not too long ago that a few years back, some bad Nosler 308 brass made it onto the market somehow. Lots of people had problems with pockets and uniformity issues.