A buddy of mine shot a buffalo with a .416, and the bullet passed through 2 chambers of the heart (according to the veterinarian who did a post mortem.) The buffalo was still on its feet after 20 minutes--just standing, so it was not pumping much blood due to exertion, but still an impressive display of "notdeqviting."

And on my only buffalo hunt, my rifle was chambered for a cartridge that started with a .4, and that felt about right.

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