It is easier to adjust 2 or 3 inches low for a 100 yard shot than it is to hold over 13 to 26 inches for a 300 or 400 yard shot.
Set your scope 2 inches high and you don't have to adjust anything from 0 to 225 or 250 yards, depending on the loads.
After 250 yards, you are going to be adjusting, anyway.
Learn your rifle.
A second solution is to have 2 loads or two sight settings.
I have a .270 with an aperture sight and a scope in a quick detachable mount. The iron sight is zeroed at 150 yards.
The scope is zeroed at 250 yards with 130-gr loads.
The rifle shoots 140-gr Hornady loads higher, so the zero is 325 yards.
