Know your game, hunting terrain, and likely range.
Sight the rifle in for a round number of that range: 100, 150, 200, 250
Practice enough to know how your rifle and loads shoot at any all all ranges where you may get a shot, using the zero range you have chosen.
If sighting in at some arbitrary fixed range works for you, go for it. I find it more useful to sight in for a maximum rise of 3�, so my zero points are rarely at some increment of 50 or 100.
