Know your game, hunting terrain, and likely range.
Sight the rifle in for a round number of that range: 100, 150, 200, 250
Practice enough to know how your rifle and loads shoot at any all all ranges where you may get a shot, using the zero range you have chosen.
Know your limit for hitting the vital zone, whether it is 3 inches, or 8 inches, from a field shooting position, and with a breeze.
Be able to estimate the range in all sorts of light.
Mark landmarks in advance when you are able, use a rangefinder when you can.
If you have target knobs on your aperture sight or scope, learn how to use them so you can avoid Kentucky holdover and windage.