I have never tried the Nosler Partition 220gr in a .308, but from my .30-06 20" tube it rings the steel with more authority than the 150gr NP's do. I'd think that will translate to a pretty hard hit on game.
It's my load for moose, if I can draw a permit!

I have a hard time calling the NP 220gr a "round nose" bullet.
With a BC of .351 and a SD of .331, it ain't a slouch.