H&S,
The Core Lokt 220's are the softest and open the quickest but I've still put them through a moose broadside. The Hornady 220's are too tough in my estimation and we've had trouble getting them to open up properly on deer even loaded hot, but that was in a 7600 Carbine.
I've only ever shot the Core-Lokt 220's, that I can recall. It seemed they were very, very soft, like 30-30 soft. I knew someone who used the Hornady for timber hunting, in 30-06 and he thought they were really hard. I recall he made comments about them being tough enough for dangerous game and talked about shooting through modest pines to see if he could stop one. That was a long time ago. I don't know of anyone who uses the big PT's.
