a good 165gr (accubond, partition, innerbond, TSX, etc) will tip moose (never shot an elk) and black bear over just fine our of a 308. seen it happen many times from 10 to 300yrds. don't see the reason why you'd want to go to a 220... but if you HAD to, I'm sure it would work just fine. 174gr @ 2400fps (303brit) kill moose and bear just fine out to 200yrds.
