Most of my loads have been 20.5 H110 over a 210 RP JSP, XTP, or SWC 215 Hardcast. I also use about 9 grains of Universal Clays for a lighter load.

21.0 of H110 has been fine, but on up to 22 it always seemed to be a bit less pleasant, and a good bit more pressure.

I have been meaning to use IMR4227 as I have heard good things. Lastly, I have more/less substituted W296 with H110.

You can get sweet speeds using hardcast, leading is something to look for, hardness, gas check or not, also a throating/forcing cone can help.