I've taken a fair number of deer with 8 grs of Unique, mostly using a 230 gr Keith but lately a 217 gr HP. That's what I used last year to take a depredation doe with at 88 yds using my OM Ruger 41 shorty. As Hawk mentions a 2 part softnose cast works well also & I've used them quite a bit. Took my Idaho bull moose & a Ruger SRH 480 with a 370 softnose cast at 45 yds off hand, one shot. Complete penetration & down in about 30 yds or so. A soft nose cast is an amazing bullet. Practice with regular bullets, hunt with the soft nose cast.

Dick