I have used Barnes since they first came out with X bullets. IME monos are different. They typically have a smaller frontal area and penetrate more. If you want DRT as in the animal doesn't move more than it's length, you need to shoot CNS. You can drive them fast but be prepared for more meat damage with less than ideal shot placement. I personally use neck shots on undisturbed game out to 100 yards or so. My experience is mostly in the west where shots can be well over 100 yards on deer which typically are not over 125lb but includes other game on other continents.YMMV
