I've owned four .41s over the years, two Ruger Bisleys, one Redhawk and a Freedom Arms 97 6 inch. The FA is the only one I still own and it gets fed a steady diet of hard cast 210s at about 1000 fps. If that's not enough oomph, I need a rifle. I've never owned a .45 Colt or a .44 Magnum - the .41 was the first magnum revolver I ever bought and I never saw a need for another magnum caliber. I do still have a .44 Special Ruger Bisley 5-1/2 inch, but that doesn't really do anything the .41 won't except provide a slightly heavier bullet at slightly greater (.019 inches) diameter.

If I ever find a reasonably priced Marlin lever in .41, I'd certainly pick it up. Sadly, they've gotten silly expensive.