The 6.5's with the Barnes 100gr TTSX will cleanly take the largest muley buck with ease. Any one who has used this bullets understands this. So, there is no reason the 110 gr mono 270 should not work easily as well. The mono bullets perform way out of what their weight would indicate. Like wise the 270 with a 130 gr mono will take elk cleanly with a complete pass thru. I have observed this success numerous times. My 270 with it's 24" Bbl will deliver in excess of 3200fps with 59.5grs of Rel 19 & the Barnes 130gr TSX / TTSX. This is an outstanding load quoted right out of the Barnes manual.. The fast time of flight & flat trajectory on my 522 yd range has proven it's ability to hit the target with authority..