I have killed 8 or 10 with a 270 and 110 grain TTSXs. My son killed 8 with his 270 and 130 TSXs. Every single one of his dropped where they stood. Some of mine never moved, the farthest one went was ~70 yards. That particular deer made the 70 yards with red soup lungs and 3/4 of the heart gone. I have never killed a deer with any mono in any caliber that needed a second dose, nor have I ever been able to correlate the hole in the animal to the caliber. To me all the holes look more or less the same. Calibers used on the deer ranged from .223 to 50 ML.