The third biggest buck on my wall was killed back in 1993 with a Remington 788 .222 and a handloaded 50 gr. Nosler solid base. He was quartering away at 125 yards and dropped at the shot. The bullet hit at the last rib on the left side and the little solid base was recovered from the right shoulder. His lungs looked like grape jelly. He field dressed 172 lbs.. Since then a bunch have fallen to my .223's firing 55 gr. Nosler solid base, 55 gr. Hornady sp, 55 gr. Winchester sp and 65 gr. Sierra Gameking btsp.. No problem or complaints with the performance of any of them.