Here is my take on caliber choice, any caliber choice.

If you have a firearm that you are confident in and can put shots on target accurately while under stress, then that is the firearm you should use. All the ballistic gelatin in the world shouldn't sway your opinion. I'd rather be armed with a 22lr that I can trust than some super boomer that makes me flinch at the mere thought of pulling the trigger. Go with what works for you. In the end, isn't that the most important factor - confidence and accuracy - that will tip the scales in your favor?