65BR: I was "weened" on Smith & Wesson revolvers for "real life" self defense - and I used them professionally for 25+ years!
I love Smith & Wesson revolvers and own more of them in the calibers you mentioned than 99.9% of any of the individual people on earth do.
Having said that when I carry for self defense and on professional assignments anymore I carry a Glock Model 22 in caliber 40 S&W with night sights and two additional high capacity magazines full of top quality self defense designed hollow-points.
Yep I'm a "wheel gun" fan but when the chips are down and on the line I depart and take up with the Glock.
Hold into the wind
VarmintGuy