I have heard rumors of 475 linebaughs having been built by boring out six shot ruger cylinders. If the six shot 45 colt cylinders could take those overloads, then the rumors of the six shooter 475's are plausible.

H-110 is my favorite big bore heavy bullet magnum powder, top accuracy and velocity with predictable pressure build is always a good thing. I have seen it do some wierd things with light bullets in the 480 and in the 357 max, but with heavy for caliber bullets in 40-50 cal it is great stuff.