It might sound strange but a RB from a ML will kill better then any modern gun. Step up to the Minie' and destruction is massive. I have well over 200 deer kills with a flint lock .45. Would you hunt elk with a 300 Weatherby and 110 gr bullets or choose a 220 gr?
It is repeated over and over a larger meplat on a revolver kills better. Not true since velocity matters. Too fast and the pressure wave from the meplat moves tissue away in a secondary wound channel. The channel will collapse without damage. So you say to speed it up or make the meplat larger. Actually you need to slow it down.