In self defense situations there is not a huge difference between the lethality of a .380 and the 44 magnum.
When did we stop talking about stopping an attack, and commence talking about lethality? The two are not the same.
My most often carried round is 9mm. But my observation on game is that the .45acp does more damage, and the .44mag does dramatically more damage - even on hares. Stats are useful, but IME, they don't account for outliers. I can't prove it statistically, but I'm going to go out on a limb and say that more damage is a good thing when that exception to the rule is in your face.
