I'm comparing two calibers shooting the same type of bullet of similar weights, and it's raised some questions for me. Since I don't reload, I've been looking at ELD-X factory offerings from Hornady, the 143 gr out of a 6.5 creed and the 145 out of a 270 Win.

The 6.5 has a higher ballistic coefficient, but the 270 Win has a muzzle velocity (according to Hornady's numbers) of 500 fps more than the 6.5. The difference in velocity narrows as distance increases - that is the effect of the higher BC of the 6.5, right? However, at 500 yards, the bullet from 270 is still 100 fps faster.

Does this mean that 270 will have much more killing power from 0-500 yards? Seems like the 500 fps at the muzzle is a significant difference, but how about the 100 fps at 500 yards? Is 100 fps enough to make a difference?

Does higher BC factor into how the bullet will perform when it actually hits the target?