Both will kill WT at "reasonable", shooters skill, ranges. If recoil and barrel life is not a problem with you, practice and rounds down range would go to the 308, IME. I`d gotten over 13k "good" rounds out of my comp. rifles when I shot HP. Don`t think you would do that round count with the 25-06. In that reguard, the 308 would be the more efficient, IMHO.