Why not a 308, I have and use a 30-06 but for deer in similar rifles with similar barrel lengths and similar bullet weights there is no real difference. In bullet weights between 150grs and 180grs the 30-06 is 80 to 100 fps faster. From a ballistic stand point a 308 at the muzzle is equal to a 30-06 at 30 yards. The 30-06 has a 30 yard advantage. In a Remington 700 SPS, both rifles having 24 inch barrels, the 30-06 is 1/2" longer and 2.4 ounces heavier. That is the basic difference between the cartridges, 100fps, 30 yards, 1/2 inch and 2.4 ounces. From a handloading standpoint the 30-06 is more versatile and the 308 is more economical and probably more accurate.