I still shoot my 7 3/4 lbs. 300 H&H well, but part of that equation is the excellent Echol's legend stock design. In the past I've had both .338 Wm and .375 H&H and they were no fun. Now day's I hunt mostly with a 280 AI .270 or 6.5 cm, but will keep taking my 300 H&H when it comes to a dedicated elk hunt, mainly cause it's brought me a lot of luck.
Having said that I've had a separated right shoulder( shooting side) for the last 10 years as well as both my rotator cuffs are torn, and at 54 things are catching up with me.