The Bob works. Grew up reading Whelan and O’Connor and got one of the first of the 1980s Featherweights as my first. As a wildlife biologist and Hunter killed over 100 white tails with every factory load available. Lost that rifle in 1999 to a house fire and my best friend gave me a Remington custom shop M7 Bob. My daughter and I killed another 50 or so with that rifle. Took my youngest stepson Colorado elk hunting and he used a Ruger 77 Ultralight Bob. We use 87 gr. or lighter for Fox/coyotes, 80 grain Barnes and 100 grain lead jacketed for deer and 100-120 Nosler partitions for Elk.
I would hunt anything anywhere with a 115gr. Nosler partition.

Note that I have killed game with everything from the Hornet to the .375 H&H. Bullet placement is more important than cartridge/Caliber.