I hunted in Mozambique last fall, and one of the rifles my son and I used was a 30-06. We also had a .375 H&H for buffalo and eland plus a .308. The 30-06 was loaded with 168 grain TTSX and performed very well on all the plains game it was used on, which included kudu and waterbuck as well as nyala, bushbuck, warthogs, reedbuck and bush pigs. My son used a .308 loaded with 150 grain TTSX to take a big sable as well as some other plains game.

I have limited experience in Africa, but from what I've seen, a 30-06 is an excellent choice for almost any plains game.