I recall the first season I was using the 143 gr. ELD-X on elk. This was during Covid when dang near anything bonded was unobtainium.

I had an elk quartering-to right around 60 yards in the dark woods. Because of the ELD-X I chose to just stare at 'em until it walked off.

Next day however, I got a nice 150 yard shot tight behind the leg crease. No drama ensued.

It's you and the bullet, and all the rest is secondary.