I’ve probably shot 40ish animals weighing from 100 to 650 pounds with either ELDX or AMAX bullets. I’ve killed LOTS more, but these would be the “big game” weight sample size. I don’t recall losing one, and anything that’s made it more than 50 yards wasn’t shot what I’d call correctly. I’ve used 75/80 grain in 22 caliber in either a 223 or 22-250, 150 gr in 7mm, and 178/210 in 30 caliber. The largest was a very large nilgai at 170 yards shot directly into the shoulder. There was no exit and he ran around 50 yards. That’s not the bullet I really wanted to use, but it’s what I had and it worked. I’ve had great luck on deer and pigs using the 150gr in my 7-08. Shots from 10-450 yards have all resulted in dead deer, and most have been dead within 10-15 yards.
