my 50 beowulf is a workable 200 yard cartridge, you have to use holdover of course but sighted in correct its on deer at 100, 150 means high, 200 means top of back. Pretty easy to remember.
Barnes X thump em pretty nicely , but I've yet to have a DRT one, but I don't break bone and such, I'm a lung shooter a lot, that or head, and I haven't done a head with the 50 yet(neither the real 50 or my beowulf....)
