Depending upon the bullet energy, bullet drop and weight of the animal hunted each cartridge has its limits. I started shooting prairie dogs in 1952 with a 22 RF rifle. Later I got a 22 WMR rifle that gave me about 50 more yards. When the 17 HMR rifles first came out I got one . I likes what the 17 HMR would do so I had to try out the little 17 HM2. At times I will shoot the 22 rimfire rifles but for prairie dogs the 17s are the only rimfire rifles I use. When I go out after bigger varmints or shooting at longer ranges I like the 22-250 or Swift but for some hunting conditions I can use the 17 Fireball, 17 Remington, 204 Ruger, and 223 rifles. When hunting, I like to be a bit over gunned for the size of the animal and the distance I will shoot them at.