In your experience.

The 17HMR is a nice cartridge, but in my experience the 22 MRF just plain kills larger critter better/faster/more reliably with the common 40 and 45 grain JSP and JSP bullets. In my experience, the 17 grain plastic tip bullets are very fragile and fast opening, great for ground squirrels, pdogs, and other small lightly constructed critters, while the JHP often don't expend much, if any, and tend to drill through/through like FMJs.

Standard disclaimer; "YMMV and since my experience is mine alone, your experience is likely to be different.".

Jeff