I've never killed a black bear or a lion, but I've had a few close encounters with both. I've had lots of "encounters" with two legged varmits and used a handgun in two such cases.
If you are more worried about two legged varmits, I wouldn't pack a revolver if I had a choice. I'd pack either a 1911 style semi auto or a SIG 220. That's because when you drop them on a hard surface, they work when you pick them up. 50% of the revolvers I've seen so dropped or used as a club in one case, would no longer fire.....
Do make sure you understand and obey the laws in the areas where you'll be. However, frankly, I can explain anything but my own death.
Will a .45 ACP or a 10mm work on a black bear or a Mtn Lion with common expanding ammo ? I understand they will. But, if you insist ona guy who has seen lots of them shot with such guns, ask JJHack. E