I've been sprayed in the eyes/face with OC in training a few times. After being sprayed, we were required to draw our PR-24 baton, administer a few jabs/strikes to a training bag, then handcuff a semi-compliant fellow student.

Bottom line, OC will make your eyes/nose burn and runny, make you wish to close your eyes, make it hard to breathe, irritate your mouth, throat, lungs, sinus.

But, if you have a strong combat mindset, and determination, it will not neutralize you.