105 Amax blew up on a deer shoulder with no penetration to vitals at ~150 yards, fired from 6mm Remington.
Local friend had a similar thing happen with 162 Amax fired from a 280 on a deer. No penetration to vitals.
Several others on the 'Fire have noted failures to penetrate from Amaxs as well.
Too many good game bullets out there to deal with a maybe bullet for hunting. I'll sure use 'em for other stuff, but not big game.