Am I overthinking bullet construction?
Yes, you are overthinking it.
You have a good grasp on how different bullets perform. Go with what you prefer.
I am a big fan of mono's. Being a long time bowhunter, I like two holes.
Being a long time meat hunter. I like less meat loss, and the lack of finding lead fragments when processing.
With all of that being said I have shot 6 deer/antelope/black bear with lead bullets over the last couple of years. 6.5 129gr Interlock, 277 143gr ELD-X, 338 200gr Ballistic silvertip and Accubond.
I did shoot my antelope last weekend with a 55gr GMX out of my 222.