In southeast, the best all around rifle I’ve found is a 9.3x62 with a 20” barrel. A 300 yard shot is rare, and either the 250s or 286s witless do that. If I lived in the interior I’d be tempted to use a .300 win/wsm with a 22” barre because bears seem to be less of a concern and it seems like everything is at least 300 yards away.